FIG. 1.

Activation of Ras interrupts IFN-induced antiviral responses. Vector control (Cont) cells (C) and RasV12 cells (V) were incubated with or without IFN (500 U/ml) for 16 h and then challenged with VSV (MOI = 1). Cytopathic effects (A) and progeny virus production (B) in vector control cells and RasV12 cells at 24 h after VSV infection are shown. *, P < 0.01. (C) Viral protein synthesis in vector control cells and RasV12 cells in the absence or presence of IFN at 0, 6, 12, 24, and 36 h after VSV infection, as determined by Western blot analysis for VSV-G and β-actin.