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Guinea pig serum responses to rVSV-gD immunization. Guinea pigs were primed intranasally with indicated doses of rVSVI-gD and boosted intranasally with the same doses of rVSVCh-gD at week 3. Sera were collected at weeks 3 and 6. (A) Individual serum samples were tested for presence of IgG anti-gD antibodies by ELISA and for anti-HSV-2 neutralizing antibodies (A) and neutralizing antibodies against VSVI and VSVCh (B).
