FIG.5.

Effects of microtubule motor inhibitors on HSV particle movement. Motility studies similar to those described in the legend of Fig. 3 were performed in the presence of AMP-PNP, sodium orthovanadate, or a mixture of the two or with buffer alone. (A) Effect of inhibitors on numbers of motile particles. The bars in the graph indicate the percentages of microtubule-bound HSV-associated particles that moved upon the addition of 500 μM ATP under each of the conditions tested. Error bars represent standard errors of the means. The number of microtubule-bound HSV particles examined in each experiment is shown in parentheses above each bar. (B) Effect of inhibitors upon the run length and velocity of particle motility. The number of runs examined under each of the four conditions is indicated in parentheses.