TABLE 2.
Protection against EDIM shedding after oral immunization with live RRV in neonatal and adult BALB/c mice challenged at 10 or 28 dpi
| Groupa | Time of challenge (dpi) | n | Quantity of antigen shed (ng/mouse/day)b | % Protectionc |
|---|---|---|---|---|
| Mock-immunized neonates | 7 | 14,205 ± 40,180 | ||
| RRV-immunized neonates | 10 | 10 | 1,183 ± 3,201d,e | 91.7 |
| Mock-immunized neonates | 8 | 2,904 ± 3,439 | ||
| RRV-immunized neonates | 28 | 8 | 8 ± 42d | 99.7 |
| Mock-immunized adults | 8 | 5,624 ± 8,789 | ||
| RRV-immunized adults | 10 | 8 | 11 ± 22d | 99.8 |
| RRV-immunized adults | 28 | 8 | 13 ± 24d | 99.8 |
a
Neonates were immunized at 7 days of age, and adults were immunized at ≥6 weeks of age.
b
Mean quantity of rotavirus antigen shed ± SD over 7 days postchallenge.
c
Percent protection represents the percent decrease in mean quantity of rotavirus antigen shed during the 7 days after challenge due to immunization.
d
Significantly (P ≤ 0.01) less than mock-immunized mice.
e
Significantly (P ≤ 0.01) greater than immunized neonatal mice challenged at 28 dpi or immunized adult mice challenged at 10 or 28 dpi.