TABLE 3.
Protection against EDIM shedding after oral immunization of adult immunologically normal (wt) or J chain knockout BALB/c mice with 108 FFU of D × RRV strain of rotavirusa
| Group | n | Quantity of rotavirus antigen shed (ng/mouse/day)b | % Protectionc |
|---|---|---|---|
| Unimmunized wt mice | 6 | 2,084 ± 3,241 | |
| D × RRV-immunized wt mice | 5 | 0.2 ± 1.0 | 99.99 |
| Unimmunized J chain KO mice | 6 | 6,149 ± 6,157 | |
| D × RRV-immunized J chain KO mice | 6 | 4,261 ± 5,480 | 30.70d |
a
Groups of mice were challenged with wt EDIM 28 days after D × RRV immunization.
b
Mean quantity of rotavirus antigen shed (± SD) for 7 days after EDIM challenge.
c
Percent protection represents the percent decrease in mean quantity of rotavirus antigen shed during the 7 days after challenge due to immunization.
d
Significantly (P < 0.001) less than in immunologically normal mice.