TABLE 4.

Neutralizing antibody titers in sera obtained from hyperimmunized or orally immunized mice determined against homotypic and heterotypic rotaviruses^a

Rotavirus strain used for immunization	GMT of neutralizing antibody against specific rotavirus strainb
	D × RRV	RRV	Wa	EDIM
D × RRV	>2,500 (156)	1,570 (38)	1,071 (<20)	<20 (<20)
RRV	>2,500 (77)	>2,500 (72)	<20 (<20)	<20 (<20)
Wa	30	<20	403	<20
EDIM	<20 (<20)	<20 (<20)	<20 (<20)	100 (<20)

^aGroups of six mice each were either hyperimmunized with purified rotaviruses or orally immunized with lysates of these viruses by the procedures described in Materials and Methods. Serum specimens collected from these animals were tested for neutralizing antibody levels against the specified viruses, and the geometric mean titers (GMTs) of these sera were calculated. The lowest titer measurable was 20, and titers below this value were set at 20 to calculate GMTs.

^bTiters not in parentheses are for sera collected from hyperimmunized mice; titers in parentheses are for sera from orally immunized mice.