TABLE 5.

CD4⁺ (with more than two subjects responding) and CD8⁺ HIV-1-specific T-cell responses (three out of five subjects mapped) induced in healthy subjects by vaccination

HIVA peptide	Position of immunogena	Protein	Sequence	CD4 dependent	No. of vaccinees responding	HLA
6	22-36	p24	AWVKVIEEKAFSPEVb	+	2	Uc
13	49-64	p24	PQDLNMMLNIVGGHQA	+	2	U
35	138-152	p24	LNKIVRMYSPVSILDb	+	2	U
42	166-180	p24	DRFFKTLRAEQATQEb	+	3	U
61	242-256	p17	GGKLDAWEKIRLRPG	+	2	U
68	270-284	p17	SRELERFALNPSLLEb	+	4	U
69	274-289	p17	ERFALNPSLLETAEGb	+	4	U
76	302-316	p17	TSEELKSLFVTVATLb	+	2	U
77	306-320	p17	LKSLFNTVATLYCVHb	+	2	U
102	430-440	gp120	TVYYGVPVWK	−	3	A*0301

^aDescribed in reference 26.

^bPeptide contains previously described promiscuously binding, immunodominant CD4 T-cell epitopes in HIV-1-infected patients (36).

^cU, HLA restriction of peptide-specific response in vaccinee not defined in this study.