TABLE 1.
Changes in viral phenotypic coreceptor tropism assignment of plasma virus
| Sample | Expression (RLU)a
|
Phenotypic tropism assignment | |
|---|---|---|---|
| CCR5 | CXCR4 | ||
| Patient A | |||
| Screen | 2,219,574 | 120 | CCR5 tropic |
| Day 1c | 948,239 | 62 | CCR5 tropic |
| Day 11 | 407,619 | 1,882 | Dualtropic/mixed tropic |
| Day 40 | 2,764,746 | 63 | CCR5 tropic |
| Patient B | |||
| Screen | 961,223 | 70 | CCR5 tropic |
| Day 1c | 814,281 | 75 | CCR5 tropic |
| Day 11 | 651,100 | 6,155 | Dualtropic/mixed tropic |
| Day 40 | 535,470 | 8,006 | Dualtropic/mixed tropic |
| Day 203 | 533,070 | 10,466 | Dualtropic/mixed tropic |
| Day 251 | 272,529 | 20,981 | Dualtropic/mixed tropic |
| Day 308 | 256,712 | 6,561 | Dualtropic/mixed tropic |
| Day 373 | 663,924 | 11,369 | Dualtropic/mixed tropic |
| Day 433 | 614,385 | 27,322 | Dualtropic/mixed tropic |
| Patient Cb | |||
| Day 1c | 109,959 | 5,684 | Dualtropic/mixed tropic |
| Day 11 | 2,258 | 58,074 | Dualtropic/mixed tropic |
| Day 40 | 153,464 | 263 | Dualtropic/mixed tropic |
a
Readings above background are shown in boldface.
b
This patient was included in the study due to a labeling error with the screening sample.
c
Day 1 samples were taken before treatment (predose).