TABLE 1.

Identification of enriched functional categories in the set of genes affected by rhinovirus infection

GO term and time pointa	Total no. of genesb	No. of down- regulated genes	No. of up-regulated genes	P valuec
RV-1 h
Transcription	1154	12	16	0.0045
Nucleus	1882	17	22	0.0111
Development	1413	9	19	0.0557
Cell cycle	543	7	6	0.0557
Protein modification	718	7	9	0.061
Signal transducer activity	1587	10	20	0.08
RV-3 h
Inflammatory response	165	1	11	0.0001
Innate immune response	168	1	11	0.0001
Transcription	1154	10	23	0.006
Signal transducer activity	1587	7	34	0.0121
Humoral immune response	147	0	7	0.019
Nucleus	1882	13	33	0.0201
Development	1413	5	30	0.0373
Glycoprotein biosynthesis	71	0	4	0.0419
Apoptosis regulator activity	100	0	4	0.0994
RV-5 h
Nucleus	1882	37	93	0
Transcription	1154	17	67	0.0002
Inflammatory response	165	1	17	0.0016
Innate immune response	168	1	17	0.002
RNA processing	144	7	7	0.0139
Amino acid activation	33	3	2	0.0238
Metabolism	4138	77	152	0.0243
Microtubule-associated complex	369	6	20	0.053
Apoptosis regulator activity	100	2	8	0.0292
Secretory pathway	87	2	6	0.0721

^aThe differentially expressed genes at each time point were annotated by GoMiner (see Materials and Methods).

^bTotal number of genes in the GO term that were present on U133A chips.

^cGO terms that were selected with a P value smaller than 0.1.