Table 1.
| Protein Name | Accession # | Tissue Distribution | KO phenotype | Rank Order Potency of Antagonists |
|---|---|---|---|---|
| NKCC1 | NM_001046 | kidney, epithelium, CNS, sensory neurons (DRG, TG, olfactory) | Male infertility, deafness, shaker, hypoalgesia | bumetanide >> piretanide > furosemide |
| NKCC2 | NM_000338 | Kidney specific | Renal insufficiency, Barrter syndrome | |
| KCC1 | NM_005072 | Ubiquitous | No KO mice | |
| KCC2 | AF208159 | CNS, not DRG, TG | CNS hyperexcitability, epileptic activity | piretanide > furosemide ≈ bumetanide |
| KCC3 | AF314956 | Ubiquitous | Sensorymotor neuropathy | |
| KCC4 | NM_006598 | Ubiquitous, little in CNS | Deafness |