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Breadth of the CD8+ T-cell response to HSV-2. The number of ORFs to which positive (≥20 SFU/106 CD8+ T cells) responses were detected is plotted versus the number of responding subjects among the 21 HSV-2-seropositive subjects with genital herpes who were assayed against the complete set of peptides covering 48 HSV-2 ORFs.
