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. 2006 May;50(5):1805–1812. doi: 10.1128/AAC.50.5.1805-1812.2006

FIG. 1.

FIG. 1.

(A) Effect of azithromycin on TER of human airway epithelia in vitro. Human airway epithelial cells were cultured on Transwell filters. After reaching confluence, azithromycin (0.4, 4.0, and 40 μg/ml) was added to the basolateral side of epithelia every 48 h for 8 days. TER was measured using a Millicell-ERS electrical resistance system. Data are given as means ± SEM (n = 3). Azithromycin increased TER in a dose-dependent manner. (B) Azithromycin increases TER in human airway epithelia. Measurements were made at day 0 (open bars), before any treatment, and at day 4 (solid bars), after four doses of 40 μg/ml azithromycin. Data are given as means ± SEM (n = 6). Forty micrograms per milliliter of azithromycin added daily increased TER significantly (P < 0.0001). (C) Growth curve. Human airway epithelial cells were cultured on 24-well plates and treated continuously with 40 μg/ml azithromycin. Data are given as means ± SEM (n = 3). Azithromycin (40 μg/ml) decreases cell proliferation. AZM, azithromycin.