TABLE 1.
Pharmacokinetic parameters of CRO and CRO/CEA complexes administered intravenously at a dose of 25 mg/kg to rats
| Parameterc | Valuea
|
|
|---|---|---|
| CRO (in saline) | CRO/CEA (in 30% PG) | |
| C0 (μg/ml) | 204.89 ± 48.6 | 166.28 ± 56.3 |
| T1/2 (h) | 0.67 ± 0.35 | 1.41 ± 0.26b |
| AUCinf (mg · h/ml) | 106.16 ± 12.8 | 199.37 ± 19.1b |
| Cl (ml/h) | 59.56 ± 7.7 | 31.53 ± 2.9b |
| Vss (ml) | 43.88 ± 0.76 | 59.40 ± 7.51b |
a
Data are presented as means±standard deviations (n = 5).
b
P < 0.01 compared to aqueous CRO.
c
C0, drug concentration in plasma at time zero; T1/2, half-life; AUCinf, area under the concentration-time curve from 0 h to infinity; Cl, clearance; Vss, volume of distribution at steady state.