TABLE 1.
MICs of β-lactams for P. aeruginosa TL-1, P. aeruginosa TL-2 clinical isolate, E. coli DH10B (pRTL-1), and E. coli DH10B reference strain
| β-Lactam(s)a | MIC (μg/ml) for:
|
|||
|---|---|---|---|---|
| P. aeruginosa TL-1 | P. aeruginosa TL-2 | E. coli DH10B (pRTL-1)b | E. coli DH10B | |
| Ticarcillin | >512 | 8 | >512 | 4 |
| Ticarcillin-CLA | 8 | 8 | 32 | 4 |
| Piperacillin | 256 | 2 | >512 | 2 |
| Piperacillin-TZB | 8 | 4 | 2 | 2 |
| Cefuroxime | >512 | >512 | >512 | 4 |
| Cefoxitin | >512 | >512 | 4 | 4 |
| Cefotaxime | >512 | 32 | 512 | <0.06 |
| Cefotaxime-CLA | 64 | 32 | 0.25 | <0.06 |
| Ceftazidime | >512 | 4 | >512 | 0.5 |
| Ceftazidime-CLA | 16 | 2 | 4 | 0.25 |
| Cefepime | 256 | 2 | >512 | <0.06 |
| Aztreonam | 512 | 4 | >512 | 0.12 |
| Imipenem | 0.5 | 1 | 0.12 | 0.12 |
a
CLA, clavulanic acid at a fixed concentration of 2 μg/ml; TZB, tazobactam at a fixed concentration of 4 μg/ml.
b
The recombinant plasmid pRLT-1 contained the blaVEB-1a gene.