TABLE 3.
Efficacy of LL-37, polymyxin B, piperacillin, and imipenem in a rat model of cecal ligation and puncture-induced peritonitis
| Treatmenta (mg/kg) | % Lethalityb | Bacterial count (CFU/ml)c in:
|
||||
|---|---|---|---|---|---|---|
| Blood | Peritoneum | Spleen | Liver | MLNs | ||
| No treatment (control group C1) | 100 | 5.0 × 107 ± 2.2 × 107 | 8.3 × 109 ± 2.4 × 109 | 5.1 × 108 ± 0.3 × 108 | 4.7 × 108 ± 2.3 × 108 | 2.7 × 109 ± 0.4 × 109 |
| LL-37 (1) | 33.3 | 8.4 × 105 ± 2.0 × 105d | 8.0 × 107 ± 2.4 × 107d | 7.2 × 106 ± 1.9 × 106d | 7.7 × 106 ± 2.3 × 106d | 5.4 × 107 ± 1.6 × 107d |
| POL-B (1) | 33.3 | 4.8 × 104 ± 1.9 × 104d | 4.1 × 106 ± 1.6 × 106d | 5.9 × 105 ± 2.1 × 105d | 6.9 × 105 ± 2.1 × 105d | 7.4 × 106 ± 2.3 × 106d |
| IMP (20) | 33.3 | 2.6 × 102 ± 0.5 × 102d,e | 4.0 × 104 ± 1.2 × 104d,e | 3.6 × 103 ± 0.7 × 103d,e | 3.8 × 103 ± 0.7 × 103d,e | 3.3 × 104 ± 0.5 × 104d,e |
| PIP (120) | 40.0 | 3.4 × 104 ± 0.4 × 104d | 3.1 × 106 ± 0.3 × 106d | 2.0 × 105 ± 9.7 × 104d | 3.5 × 105 ± 0.7 × 105d | 1.6 × 106 ± 8.3 × 105d |
a
POL-B, polymyxin B; IMP, imipenem; PIP, piperacillin.
b
Lethality was monitored for 72 h following the challenge.
c
Mean ± SD.
d
P < 0.05 (familywise significance level) versus the control group C1.
e
P < 0.05 (familywise significance level) versus LL-37-, PIP-, and POL-B-treated groups.