Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effect of human serum on the 48-h IC50s and IC90s of VX-950a
| Concn of human serum (%) | IC50 (μM) | IC90 (μM) | CC50 (μM) |
|---|---|---|---|
| 0 | 0.33 | 0.79 | >30 |
| 10 | 0.88 | 1.37 | >30 |
| 20 | 1.40 | 2.52 | >30 |
| 40 | 3.45 | 4.76 | >100 |
Human serum was added to cell culture medium for a final concentration of 0%, 10%, 20%, or 40% (vol/vol), along with 0.03, 0.1, 0.3, 1, 3, or 10 μM VX-950 or 0.5% DMSO (no-compound control). The IC50s, IC90s, and CC50s were determined after a 48-h incubation.
