TABLE 2.

CalcuSyn analysis of VX-950 and IFN-α combination

Ratio (VX-950:IFN-α)a	Combination indexb:
	At IC50	At IC75	At IC90
1:100	1.24	0.73	0.56
3:100	0.74	0.53	0.53
9:100	0.77	0.58	0.61
27:100	0.67	0.61	0.68

^aIn each ratio, three to four different combinations of VX-950 and IFN-α were included. For example, the 1:100 ratio includes VX-950 plus IFN-α at 0.037 μM plus 3.7 U/ml, 0.11 μM plus 11.1 U/ml, 0.33 μM plus 33.3 U/ml, and 1.0 μM plus 100 U/ml.

^bIC₅₀s, IC₇₅s, or IC₉₀s are concentrations of the compounds that achieve 50%, 75%, or 90% inhibition, respectively. The values of the combination index at various percentages of inhibition were calculated using the CalcuSyn program as described in Materials and Methods.