TABLE 1.
In vitro efficacy of various compounds against Nipah virus replicationa
| Compound | Concn range (μg/ml) | Inhibitory concn (μg/ml)b |
|---|---|---|
| C-c3 Ado* | 0.250-8 | >8 |
| (−)-5′ Noraristeromycin* | 0.125-4 | >4 |
| DHCaA* | 0.125-4 | >4 |
| Ribavirin* | 1.56-100 | 100 |
| EICAR* | 0.250-8 | 1 |
| Pyrazofurin | 0.125-4 | 0.125 |
| Carbodine* | 0.250-8 | >8 |
| 6-Aza-uridine* | 0.125-4 | 0.25 |
| Poly(I)-poly(C12U)† | 6.25-200 | ≤6.25 |
a
The effect on Nipah virus replication was tested in Vero E6 cells (*) or HeLa (†) cells in 96-well microplates, and the effects on CPE were evaluated. Each concentration was tested in 8 wells.
b
The inhibitory concentration was defined as the lowest concentration completely abolishing CPE in the 8 wells tested. These results were obtained in two experiments.