TABLE 2.
Hamster group | Animal no. | No. of days p.i.a | Liver
|
Lung
|
Kidney
|
Spleen
|
Brain
|
Serum IgG | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Titer (PFU/ml) | RT-PCR | Titer (PFU/ml) | RT-PCR | Titer (PFU/ml) | RT-PCR | Titer (PFU/ml) | RT-PCR | Titer (PFU/ml) | RT-PCR | ||||
Control | M1 | 5 | 8.25 × 103 | + | 6.75 × 103 | + | 2.25 × 103 | + | 5.12 × 103 | + | <20 | + | NDb |
M2 | 4 | 9.75 × 103 | + | 1.28 × 103 | + | 1.43 × 103 | + | 1.01 × 105 | + | 2.5 × 101 | + | − | |
6-Aza-uridine | A1 | 6 | 5 × 103 | + | 1.71 × 104 | + | 6.12 × 102 | + | 1.01 × 104 | + | 10 × 102 | + | − |
A2 | 5 | 1.75 × 102 | + | ND | + | <20 | − | ND | + | ND | ND | ND | |
A3 | 6 | 9 × 103 | + | 1.21 × 104 | + | 7.25 × 102 | + | 1.37 × 104 | + | 6.25 × 101 | + | − | |
A5 | 5 | 4.25 × 103 | + | 1.4 × 104 | + | 4.25 × 102 | + | 4.37 × 103 | + | 3.75 × 101 | + | + | |
Ribavirin | R1 | 5 | 1.75 × 103 | + | 8 × 103 | + | 1.10 × 103 | + | 1 × 104 | + | <20 | + | − |
R2 | 7 | 1 × 102 | + | 1.45 × 104 | + | 8.62 × 103 | + | 1.91 × 103 | + | 3.13 × 102 | + | − | |
R4 | 6 | 7.12 × 103 | + | 7.8 × 104 | + | 7 × 103 | + | 1.10 × 103 | + | 4.90 × 103 | + | − |
Number of days postinfection at the time of the tests.
ND, test not done.
These tests were performed on the day of the animal's death.