TABLE 3.
Nipah virus detection by cell culture titration, RT-PCR, and serological testing in experiment 2c
| Hamster group | Animal no. | No. of days p.i.a | Liver
|
Lung
|
Kidney
|
Spleen
|
Brain
|
Serum IgG at day p.i.:
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Titer (PFU/ml) | RT-PCR | Titer (PFU/ml) | RT-PCR | Titer (PFU/ml) | RT-PCR | Titer (PFU/ml) | RT-PCR | Titer (PFU/ml) | RT-PCR | 6 | 12 | 30 | |||
| Control | H1 | 6 | NDb | ND | ND | ND | ND | ND | ND | ND | ND | ND | + | ||
| H6 | 12 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | − | + | ||
| Ribavirin | H9 | 7 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | + (day 7) | ||
| H11 | 12 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | + | |||
| H12 | 6 | <20 | + | 2.3 × 102 | + | 3.4 × 102 | + | <20 | + | ND | ND | − | |||
| Poly(I)-poly(C12U) | H13 | 30 | <20 | + | <20 | − | <20 | − | <20 | − | <20 | ND | + | + | |
| H14 | 30 | <20 | − | <20 | − | <20 | − | <20 | − | <20 | − | + | + | ||
| H15 | 30 | <20 | − | <20 | − | <20 | − | <20 | − | <20 | − | + | + | ||
| H16 | 15 | <20 | + | <20 | + | <20 | + | <20 | + | 4.4 × 102 | + | + | |||
| H17 | 30 | <20 | + | <20 | − | <20 | − | <20 | − | <20 | − | − | + | ||
| H18 | 30 | <20 | + | <20 | − | <20 | − | <20 | − | <20 | − | + | + | ||
a
Number of days postinfection at the time of autopsy.
b
ND, test not done.
c
Autopsy was performed on none of the hamsters of the control group, one of the six hamsters in the ribavirin group, and all six hamsters in the poly(I)-poly(C12U) group. Blood samples were collected from two of the six hamsters of the control group and three of the six hamsters in the ribavirin group at the time of death and from all six hamsters in the poly(I)-poly(C12U) group 12 and 30 days after infection.