Abstract
Guide RNAs (gRNAs) are small, metabolically stable RNA molecules which perform a pivotal, template-like function during the RNA editing process in kinetoplastid protozoa. The gRNA database currently contains 250 guide RNA sequences as well as secondary and tertiary structure models and other relevant information. The database is made available as a hypertext document accessible via the World Wide Web (WWW) at the URL: http://www.biochem.mpg.de/ goeringe/
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Selected References
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- Hermann T., Schmid B., Heumann H., Göringer H. U. A three-dimensional working model for a guide RNA from Trypanosoma brucei. Nucleic Acids Res. 1997 Jun 15;25(12):2311–2318. doi: 10.1093/nar/25.12.2311. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kable M. L., Heidmann S., Stuart K. D. RNA editing: getting U into RNA. Trends Biochem Sci. 1997 May;22(5):162–166. doi: 10.1016/s0968-0004(97)01041-4. [DOI] [PubMed] [Google Scholar]
- Kim K. S., Teixeira S. M., Kirchhoff L. V., Donelson J. E. Transcription and editing of cytochrome oxidase II RNAs in Trypanosoma cruzi. J Biol Chem. 1994 Jan 14;269(2):1206–1211. [PubMed] [Google Scholar]
- Köller J., Müller U. F., Schmid B., Missel A., Kruft V., Stuart K., Göringer H. U. Trypanosoma brucei gBP21. An arginine-rich mitochondrial protein that binds to guide RNA with high affinity. J Biol Chem. 1997 Feb 7;272(6):3749–3757. doi: 10.1074/jbc.272.6.3749. [DOI] [PubMed] [Google Scholar]
- Schmid B., Riley G. R., Stuart K., Göringer H. U. The secondary structure of guide RNA molecules from Trypanosoma brucei. Nucleic Acids Res. 1995 Aug 25;23(16):3093–3102. doi: 10.1093/nar/23.16.3093. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yasuhira S., Simpson L. Guide RNAs and guide RNA genes in the cryptobiid kinetoplastid protozoan, Trypanoplasma borreli. RNA. 1996 Nov;2(11):1153–1160. [PMC free article] [PubMed] [Google Scholar]