Ad:IFNG transduced TG cells are less susceptible to HSV-1 infection. Primary TG cells were transduced with 0.1, 0.5, 1.0, or 5.0 U Ad:IFNG or Ad:Null. Twenty four hr post-transduction, the cells were infected with HSV-1 (MOI = 1.0). Twenty four hr post-infection, viral titers were determined in the supernatant of each culture. The data represent cumulative means ± SEM from 3 separate experiments (n = 7), **p < 0.01) comparing the Ad:IFNG transduced cultures (0.5-5.0 transducing units) to the Ad:Null transduced cultures.