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. 2001 Jan 30;98(3):1148–1153. doi: 10.1073/pnas.98.3.1148

Figure 1.

Figure 1

Auto-Abs in BALB/c mice immunized with the 16/6Id. BALB/c mice (five mice per group) were immunized with 16/6 Id and concomitantly injected with pCDR1 or reversed pCDR1(100 μg/mouse i.v. once per week for 5 weeks) or were not treated. Results expressed as OD ± SD were obtained at the bleeding before sacrifice and represent all monthly bleedings. (A) Anti-DNA Ab titers measured on individual sera (dilution 1:1,000). (B) Anti-16/6Id Ab titers measured on individual sera (dilution 1:10,000). (C) Abs to nuclear antigens measured on pooled sera (dilution 1:100). OD levels of normal sera and of sera of mice that were injected only with pCDR1 were undetectable. The results are representatives of three experiments. (A) *, P < 0.05 as compared with reversed pCDR1-treated mice. †, P < 0.01 as compared with 16/6Id immunized untreated mice. (B) $, P < 0.05 as compared with 16/6Id immunized untreated or * 16/6Id immunized and reversed pCDR1-treated mice.