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. 2001 Jan 30;98(3):1148–1153. doi: 10.1073/pnas.98.3.1148

Figure 3.

Figure 3

Anti-DNA Abs in sera of SLE-afflicted BALB/c mice that were treated with pCDR1. BALB/c mice (20 mice/group) were immunized and boosted with 16/6Id. Later (3.5 months) mice were treated with pCDR1 i.v. or s.c., 100 μg/mouse once per week for 10 weeks. ⧫, 16/6Id immunized; ○, 16/6Id immunized and treated with pCDR1 i.v.; ▴, 16/6Id immunized and treated with pCDR1 s.c.; □, sera of normal mice. Results expressed as OD ± SD were obtained at bleeding before death and represent all previous bleedings. Results were reproducible in three independent experiments. *, P < 0.01 as compared with both pCDR1-treated groups.