Table 4.
Cytokine profile in BALB/c mice that were treated with pCDR1 for the prevention of experimental SLE
| Cytokine | Cytokine secretion
|
||
|---|---|---|---|
| 16/6Id, pg/ml | 16/6Id + pCDR1, pg/ml | 16/6Id + reversed pCDR1, pg/ml | |
| IL-2 | 800 ± 141 | <60 | 806 ± 137 |
| INFγ | 9,000 ± 816 | 267 ± 94 | 8,000 ± 2,160 |
| TNFα | 470 ± 30 | <20 | 590 ± 10 |
| TGFβ | 2,350 ± 150 | 4,300 ± 300 | 2,900 ± 100 |
Secretion of cytokines was determined by ELISA (see Materials and Methods) of supernatants of LNC stimulated with the 16/6Id. Results are of mice killed 1 month after booster injection with the 16/6Id (≈2 weeks after treatment). The results are representative of two experiments.