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Flt3 impairs pro-B cell formation in vitro. (A) Cloning frequency of B and myeloid lineage progenitors transduced with MigR1 or MigR1–Flt3. Data from the same experiment are linked by a line. (B) GFP+ pro-B cells were cultured in IL-7 plus the indicated amounts of Flt3L for 72 h. The mean live cell number of triplicate wells ± SD is shown. (C) Multistep model of B-cell lineage commitment. Key transcriptional regulators and cell surface molecules are shown.
