TABLE 1.
Peptide | Sequencea | [θ]222b | α-Helix (%) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pep3 | W | K | L | F | K | K | I | L | K | V | L-NH2 | −9,048 | 23.5 |
BP01 | W | K | L | F | K | K | I | L | K | V | L-OH | NDc | ND |
BP02 | K | L | F | K | K | I | L | K | K | L-NH2 | ND | ND | |
BP03 | K | L | F | K | K | I | L | K-NH2 | ND | ND | |||
BP04 | W | K | L | F | K-NH2 | ND | ND | ||||||
BP05 | W | K | L | F | K-OH | ND | ND | ||||||
BP06 | K | I | L | K | V | L-NH2 | ND | ND | |||||
BP07 | K | I | L | K | V | L-OH | ND | ND | |||||
BP08 | Ac-W | K | L | F | K | K | I | L | K | V | L-NH2 | −10,851 | 29.5 |
BP09 | Ts-W | K | L | F | K | K | I | L | K | V | L-NH2 | −13,341 | 37.8 |
BP10 | Bz-W | K | L | F | K | K | I | L | K | V | L-NH2 | −13,119 | 37.1 |
BP11 | Bn-W | K | L | F | K | K | I | L | K | V | L-NH2 | −10,665 | 28.9 |
BP12 | Pam-W | K | L | F | K | K | I | L | K | V | L-NH2 | ND | ND |
BP13 | F | K | L | F | K | K | I | L | K | V | L-NH2 | ND | ND |
BP14 | Y | K | L | F | K | K | I | L | K | V | L-NH2 | ND | ND |
BP33 | L | K | L | F | K | K | I | L | K | V | L-NH2 | −8,918 | 23.1 |
BP15 | K | K | L | F | K | K | I | L | K | V | L-NH2 | −9,892 | 26.3 |
BP16 | K | K | L | F | K | K | I | L | K | K | L-NH2 | ND | ND |
BP76 | K | K | L | F | K | K | I | L | K | F | L-NH2 | −9,188 | 24.0 |
BP17 | W | K | L | F | K | K | I | L | K | K | L-NH2 | ND | ND |
BP18 | W | K | L | F | K | K | I | L | K | W | L-NH2 | −8,922 | 23.1 |
BP19 | W | K | L | F | K | K | I | L | K | F | L-NH2 | −9,950 | 26.5 |
BP20 | W | K | L | F | K | K | I | L | K | Y | L-NH2 | −10,316 | 27.7 |
Boldfaced letters indicate the modifications introduced into the Pep3 sequence. Ac, acetyl; Ts, tosyl; Bz, benzoyl; Bn, benzyl; Pam, palmitoyl.
Determined in 50% trifluoroethanol in 10 mM sodium phosphate buffer (pH 7.4).
ND, not determined.