TABLE 2.
Antimicrobial activity against three plant-pathogenic bacteria and cytotoxicity of selected peptides
| Peptide | MIC (μM)
|
ED50 (μM)
|
HD50 (μM) | ||||
|---|---|---|---|---|---|---|---|
| E. amylovora | P. syringae | X. vesicatoria | E. amylovora | P. syringae | X. vesicatoria | ||
| Pep3 | 7-10 | 7-10 | 7-10 | 5.5 | 5.5 | 3.6 | 104 |
| BP08 | 10-12 | 7-10 | 2-5 | 9.0 | 4.3 | 2.0 | 17 |
| BP09 | 12-15 | 12-15 | <2 | 11.2 | 6.9 | NDa | 10 |
| BP10 | 15-20 | 15-20 | <2 | 15.1 | 9.5 | ND | 11 |
| BP11 | 7-10 | 5-7 | 2-5 | 5.0 | 3.8 | 2.5 | 30 |
| BP12 | 50-100 | 50-100 | 25-50 | 60.0 | 56.8 | 14.7 | 6 |
| BP15 | 5-7 | 2-5 | 12-15 | 4.3 | 1.6 | 7.3 | 334 |
| BP18 | 5-7 | 5-7 | <2 | 3.0 | 2.5 | ND | 26 |
| BP19 | 5-7 | 5-7 | <2 | 1.3 | 1.9 | ND | 32 |
| BP20 | 2-5 | 2-5 | 2-5 | 3.2 | 2.7 | 2.3 | 42 |
| BP33 | 5-7 | 5-7 | 10-12 | 4.3 | 3.2 | 4.1 | 190 |
| BP76 | 2-5 | 2-5 | 2-5 | 2.5 | 2.1 | 1.9 | 203 |
| Cecropin Ab | <1 | <1 | <1 | <0.3c | <0.3 | <0.3 | ND |
a
ND, not determined.
b
Cecropin A was included for comparison purposes.
c
Estimated visually from graphs; lowest concentration tested.