Table 1.

Association between birth cross and susceptibility to EAE pathology

Independent variable	Odds ratio	95% CI*	P
Simple logistic regression model
Birth cross
BS × BS	1.00†
BS × SB	2.31	1.30, 4.11	<0.01
SB × SB	2.41	1.40, 4.16	<0.01
SB × BS	2.01	1.22, 3.32	<0.01
Post-hoc analysis
BS × BS < BS × SB = SB × SB = SB × BS
Multiple logistic regression model‡
Birth Cross
BS × BS	1.00†
BS × SB	1.83	1.01, 3.31	<0.05
SB × SB	2.10	1.20, 3.67	<0.01
SB × BS	1.88	1.12, 3.14	<0.05
Post-hoc analysis
BS × BS < BS × SB = SB × SB = SB × BS
Multiple logistic regression model stratified by sex§
Females
BS × BS	1.00†
BS × SB	2.58	1.02, 6.49	<0.05
SB × SB	2.58	1.11, 6.02	<0.05
SB × BS	2.12	1.00, 4.47	<0.05
Post-hoc analysis
BS × BS < BS × SB = SB × SB = SB × BS
Males
BS × BS	1.00†
BS × SB	1.34	0.60, 2.98
SB × SB	1.76	0.84, 3.72
SB × BS	1.64	0.79, 3.39
Post-hoc analysis
BS × BS = BS × SB = SB × SB = SB × BS

*Confidence interval.

^†Reference variable. Both SC and brain showed the same significant trends separately (data not shown).

^‡Adjusted for sex, age, and season at immunization.

^§Adjusted for age and season at immunization.