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. 2006 May 11;103(21):8090–8095. doi: 10.1073/pnas.0601083103

Fig. 7.

Fig. 7.

Hypothetical model for SOHLH1 role in early folliculogenesis. SOHLH1 regulates a number of genes that are required for early oocyte development. The SOHLH1 interacting partner is unknown. (Step 1) The homeobox gene Lhx8 is likely a direct transcriptional target of SOHLH1, but genes downstream of LHX8 in the oocyte are unknown. (Step 2) Zp1 and Zp3 are likely directly regulated by SOHLH1, possibly in conjunction with FIGLA. (Step 3) Figla is partially down-regulated in Sohlh1 null oocytes, but Zp2, which is controlled by the FIGLA/E12 complex, is not significantly changed. (Step 4) The oocyte-specific homeobox gene, Nobox, is downstream of SOHLH1. Loss of Nobox expression in Sohlh1 null oocytes also results in loss of genes downstream of the NOBOX pathway, such as Gdf9 and Pou5f1. (Step 5) It is likely that SOHLH1 has additional target genes. Dotted lines indicate unknown pathways. Solid lines indicate direct transcriptional regulation.