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Activation of D2Rs inhibits glutamate release at the corticostriatal synapse. (A) Schematic illustration of the corticostriatal slice preparation. Note that the stimulating electrode illustrated is placed in the cortex outside of the white matter. (B) Quinpirole inhibits EPSCs when a three-pulse train is used. (C) A two-pulse train is also effective in revealing D2R-mediated inhibition of EPSCs. Inhibition is blocked by pretreatment with sulpiride, a D2R antagonist.
