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Activation of CB1 receptors is necessary for HF-specific inhibition. (A) Application of AM251 blocked synaptic depression produced by quinpirole. (B) Pretreatment with WIN552,12-2, a CB1 receptor agonist, occluded the quinpirole-induced inhibition. (C and D) Quinpirole-induced synaptic depression was normal in wild-type mice (C) but absent in CB1 knockout mice (D). (Scale bars: 100 pA, 25 ms.)
