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Quinpirole-induced, frequency-dependent inhibition is observed under more physiological conditions. (A) No inhibition of EPSPs measured in current-clamp mode was observed with 1-Hz stimulation. (B) Significant inhibition of EPSPs was observed with 20-Hz stimulation. (C) Inhibition of EPSPs at 20 Hz was blocked by intracellular loading of the calcium chelator EGTA.
