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PcGs bind to genes that are repressed or induced during neuronal differentiation. (A) Models for how PcGs could regulate gene expression during terminal differentiation. (B) qPCR and ChIP analysis of two PcG target genes (ZIC1 and MEIS2) induced during neuronal differentiation of NT2/D1 cells treated with 1 μM RA. (C) qPCR and ChIP analysis of two genes (NEUROG2 and OLIG2) repressed during neuronal differentiation of NT2/D1 cells treated with 1 μM RA.
