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Kd values for short DNA substrate saturation by MthMCM proteins (nM 12-mer)
| ssDNA |
dsDNA |
|||
|---|---|---|---|---|
| −ATP | +ATP | −ATP | +ATP | |
| WT | 60 ± 21 | 65 ± 8 | ND* | ND |
| R98A | >100 | 66 ± 30 | 428 ± 148 | ND |
| Δ597 | 8 ± 2 | >225 | 34 ± 8 | ND |
| RAΔC | >100 | >225 | 58 ± 16 | ND |
*ND Kd in all cases is >1 μM 12-mer.
