Table 2.
Cluster analysis of Group I (up-regulated) and Group II (down-regulated) genes
| Category | Group I | Group II |
|---|---|---|
| Cellular metabolism | 229 (34.9) | 39 (45.3) |
| Catalytic activity | 180 (27.4) | 32 (37.2) |
| Cell growth and/or maintenance | 149 (22.7) | 28 (32.6) |
| Protein binding | 118 (18.0) | 18 (20.9) |
| Protein metabolism | 97 (14.8) | 17 (19.8) |
| Purine nucleotide binding | 70 (10.7) | 11 (12.8) |
| Hydrolase activity | 69 (10.5) | 14 (16.3) |
| DNA binding | 66 (10.0) | 12 (14.0) |
| Development | 65 (9.9) | 0 (0.0) |
| Transferase activity | 65 (9.9) | 11 (12.8) |
| Protein modification | 50 (7.6) | 13 (15.1) |
| Intracellular signaling cascade | 42 (6.4) | 0 (0.0) |
| Cell proliferation | 41 (6.2) | 13 (15.1) |
| Transcription regulator activity | 37 (5.6) | 7 (8.1) |
| Kinase activity | 34 (5.5) | 8 (9.3) |
| Cell cycle | 33 (5.0) | 10 (11.6) |
| Intracellular transport | 31 (4.7) | 6 (7.0) |
| RNA binding | 32 (4.9) | 0 (0.0) |
| Protein localization | 29 (4.4) | 0 (0.0) |
| Cytoskeleton organization and biogenesis | 24 (3.7) | 5 (5.8) |
| Lipid metabolism | 22 (3.3) | 0 (0.0) |
| Apoptosis | 20 (3.0) | 0 (0.0) |
| Ligase activity | 19 (2.9) | 0 (0.0) |
| Cytoskeletal protein binding | 16 (2.4) | 4 (4.7) |
| Reproduction | 15 (2.3) | 0 (0.0) |
| Biological process not annotated | 245 (37.3) | 8 (9.3) |
| Molecular function not annotated | 218 (33.2) | 3 (3.5) |
| Total probe sets | 657 | 86 |
The values in parentheses represent percentages. Proteins with multiple functions or involvement in several biological processes were counted in multiple annotation categories. The genes were annotated by Gene Ontology biological process and Gene Ontology molecular function using david 2.1. The annotation was performed with these settings: threshold of minimum gene counts, 2; maximum P value, 0.1.