Table 2.
RNA expression levels for selected human genes
| Gene name | GenBank accession no. | Liver |
Blood |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NG | TG1 | TG2 | H | NG | TG1 | TG2 | TG3 | H | ||
| Shared | ||||||||||
| Signal recognition particle 9 kDa | NM_003133 | 19 ± 8 | 44 ± 3 | 64 ± 22 | 867 ± 146 | 6 ± 5 | 52 ± 81 | 37 ± 36 | 574 | 1,120 ± 108 |
| Transmembrane protein 14B | NM_030969 | 6 ± 5 | 137 ± 131 | 55 ± 5 | 260 ± 48 | 28 ± 27 | 53 ± 14 | 57 ± 16 | 257 | 259 ± 76 |
| Histamine N-methyltransferase | BC005907.1 | 14 ± 2 | 94 ± 19 | 43 ± 1 | 239 ± 135 | 17 ± 3 | 71 ± 39 | 85 ± 56 | 51 | 121 ± 17 |
| KIAA0494 gene product | AK001487.1 | 19 ± 13 | 137 ± 1 | 54 ± 11 | 128 ± 6 | 17 ± 3 | 78 ± 76 | 19 ± 1 | 116 | 257 ± 49 |
| SSR1 signal sequence receptor α | AI016620 | 16 ± 8 | 213 ± 183 | 39 ± 11 | 101 ± 13 | 19 ± 15 | 56 ± 31 | 49 ± 39 | 178 | 116 ± 24 |
| Liver-specific | ||||||||||
| Solute carrier family 16 | NM_004731 | 9 ± 0 | 81 ± 78 | 93 ± 33 | 195 ± 32 | |||||
| Microtubule-associated protein 7 | T62571 | 11 ± 8 | 87 ± 38 | 52 ± 53 | 169 ± 21 | |||||
| Erythrocyte membrane protein band 4.1-like 2 | NM_001431 | 8 ± 3 | 122 ± 162 | 89 ± 60 | 168 ± 62 | |||||
| Septin10 | BF981643 | 10 ± 1 | 52 ± 14 | 54 ± 17 | 89 ± 42 | |||||
| Hypothetical protein | NM_024510 | 9 ± 3 | 136 ± 159 | 67 ± 69 | 78 ± 27 | |||||
| Hypothetical protein | BF219234 | 7 ± 4 | 70 ± 42 | 80 ± 63 | 66 ± 12 | |||||
| Glycoprotein VI (platelet) | AB043821.1 | 10 ± 2 | 123 ± 151 | 64 ± 6 | 64 ± 17 | |||||
| Hypothetical protein | NM_017792 | 12 ± 9 | 236 ± 171 | 31 ± 12 | 62 ± 6 | |||||
| cAMP-regulated guanine nucleotide exchange factor | NM_007023 | 3 ± 0 | 78 ± 25 | 59 ± 37 | 53 ± 13 | |||||
| Glioblastoma amplified sequence | NM_001483 | 9 ± 1 | 136 ± 151 | 70 ± 37 | 51 ± 9 | |||||
| Blood-specific | ||||||||||
| Dicer1 homolog (Drosophila) | BG109746 | 7 ± 5 | 86 ± 65 | 56 ± 9 | 24 | 421 ± 34 | ||||
| Similar to heterogeneous nuclear ribonucleoprotein A3 (hnRNPA3) (LOC285292) | BE867771 | 6 ± 4 | 57 ± 72 | 47 ± 52 | 465 | 322 ± 96 | ||||
| Phosphatidylinositol binding clathrin assembly protein | AL135735 | 3 ± 1 | 42 ± 38 | 34 ± 7 | 212 | 225 ± 76 | ||||
| Estrogen-related receptor β-like 1 | NM_018010 | 8 ± 7 | 91 ± 72 | 33 ± 21 | 71 | 82 ± 3 | ||||
| Hypothetical protein | AI809961 | 7 ± 7 | 24 ± 9 | 88 ± 34 | 102 | 89 ± 48 | ||||
| Integrin β5 | AI335208 | 4 ± 0 | 49 ± 39 | 25 ± 11 | 253 | 83 ± 24 | ||||
| 5-Azacytidine-induced gene 2 | NM_022461 | 6 ± 6 | 83 ± 71 | 21 ± 22 | 535 | 79 ± 30 | ||||
| Cofactor required for Sp1 activation subunit 2 | AI971089 | 5 ± 1 | 61 ± 94 | 18 ± 19 | 396 | 51 ± 2 | ||||
Affymetrix signal levels are shown for human genes that were consistently detected in blood or liver from at least one transplant goat. Data columns for normal goats (NG), transplant goats (TG), and normal human (H) are shown with the mean and standard deviation of three replicate GeneChip assays (except for TG3, where only one sample was assayed). Genes that showed specific and consistent expression (low standard deviation for the individual mean) in at least one transplant goat are listed. Additional annotations are available by using the GenBank accession number (www.ncbi.nlm.nih.gov/entrez). Genes confirmed in Fig. 4 are indicated in bold.