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Inhibition and kinetic data for human FPPS and N-BPs
| Constant | IPP | GPP | Inhibitor |
|
|---|---|---|---|---|
| RIS | ZOL | |||
| Km, μM | 1.8 ± 0.33 | 2.07 ± 0.2 | ||
| kcat, s−1 | 0.42 | |||
| IC50, nM | ||||
| Initial | 450 ± 10 | 475 ± 10 | ||
| Preincubated | 5.7 ± 0.54 | 4.1 ± 0.22 | ||
| Ki, nM | 72 ± 4 | 76 ± 3 | ||
| Ki*app, nM | 2.0 ± 0.44 | 0.4 ± 0.1 | ||
| Ki*, nM | 0.34 | 0.07 | ||
| k5/k6 | 210:1 | 1080:1 | ||
