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Deletion of LIF increases the severity of cuprizone-mediated oligodendrocyte loss. Representative frozen sections within the medial corpus callosum of LIF−/− mice and wild-type controls were stained for the oligodendrocyte marker CC1. Mice were either unchallenged or given cuprizone for 3 weeks. Arrows indicate examples of CC1-positive cells. (Scale bar, 25 μm.)
