Spontaneous bidirectional VT and MAP alternans in a calstabin-2+/− mouse (no pacing). (A) Simultaneous, representative ECG lead I tracing and left ventricular epicardial MAP recording from a placebo-treated calstabin-2+/− mouse during early phase of sVT. CL, cycle length. Bidirectional ECG QRS alternans and MAP alternans are closely correlated. (B) Bar graphs summarizing alternans (Left), sVTs (Center), or nsVTs (Right) in placebo-treated (J−) or JTV519-treated (J+) calstabin-2+/− (open bars) or calstabin-2−/− (filled bars) mice during ISO stimulation. GT, genotype.