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. 2006 May 3;103(20):7906–7910. doi: 10.1073/pnas.0602133103

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© 2006 by The National Academy of Sciences of the USA

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Fig. 5. — JTV519 increased calstabin-2 binding to RyR2 in cardiomyocytes during β-AR stimulation. (A) RyR2 immunoprecipitation from calstabin-2^+/− cardiomyocyte lysate demonstrating increased PKA phosphorylation of RyR2 at Ser-2808 and calstabin-2 depletion after a 30-min exposure to 100 nM isoproterenol (ISO). Pretreatment with 1 μM JTV519 prevented calstabin-2 release from RyR2 despite PKA Ser-2808 phosphorylation. (B) Bar graphs summarizing results from three myocyte isolations each assessed in triplicate. ∗, P < 0.05.