TABLE 1.
GST-M2 binding to SH3 domains from human proteins
| SH3 domains present ina:
| ||
|---|---|---|
| Array I | Array II | Array III |
| Amphiphysin | Abl interactor protein 2 | Arginine N-methyltransferase 2 |
| Discs large homolog 2 | Phosphatidylinositol 3-kinase regulatory alpha subunit | Growth factor receptor-bound protein 2, SH3 domain 1 |
| Vav1 proto-oncogene, SH3 domain 1 | GRB2-related adaptor protein, SH3 domain 1 | Myosin-IE |
| Beta-lymphocyte-specific protein tyrosine kinase | Vav2 protein, SH3 domain 1 | SH3 protein interacting with Nck, 90 kDa |
| Human T-lymphocyte-specific protein tyrosine kinase p56 LCK | Grb2-related adaptor protein 2, SH3 domain 1 | Grb2-related adaptor protein 2, SH3 domain 1 |
| 55-kDa erythrocyte membrane protein | Channel-associated protein of synapse 110 | Grb2-D2 growth factor receptor-bound protein 2, SH3 domain 2 |
| Cytoplasmic protein NCK1, SH3 domain 3 | c-Jun-amino-terminal kinase interacting protein 1 | MYIF myosin-IF |
| Abelson tyrosine kinase | Vav3 protein, SH3 domain 1 | Triple functional domain protein |
| Spectrin alpha chain (nonerythrocytic) | Abelson-related protein, Arg | Bullous pemphigoid antigen |
| Cellular Gardner-Rasheed feline sarcoma virus protein | Stac protein | Grb-2 related adaptor protein 2, SH3 domain 2 |
| PAK-interacting exchange factor beta | Mitogen-activated protein kinase kinase kinase 10 | Neutrophil oxidase factor (p47-phox) (47-kDa), SH3 domain 1 |
| Phospholipase C gamma-1 | Vav3 protein, SH3 domain 2 | VINE-D2 vinexin, SH3 domain 2 |
| Cortactin | Dihydropyridine-sensitive L-type, calcium channel beta-1 subunit | Voltage-dependent calcium channel beta-2 subunit |
| Proto-oncogene tyrosine protein kinase FYN | Intersectin 1, SH3 domain 3 | |
| Peroxisomal membrane protein PEX13 | Tyrosine protein kinase Tec | Neutrophil oxidase factor (p47-phox) (48-kDa), SH3 domain 2 |
| Retinoblastoma protein-interacting zinc-finger | Myosin VIIa | Cellular Rous sarcoma viral oncogene homolog |
| Mixed-lineage kinase 3 | Vinexin, SH3 domain 1 | Proto-oncogene CRK, SH3 domain 1 |
| Nebulin | CRK-like protein, SH3 domain 1 | Intersectin 1, SH3 domain 4 |
| Bruton tyrosine kinase | Cdc42-interacting protein 4 | Cytoplasmic protein NCK2, SH3 domain 1 |
| Phosphoinositide 3-kinase regulatory beta subunit | Cytoplasmic protein NCK2, SH3 domain 2 | Proto-oncogene CRK, SH3 domain 2 |
| Yamaguchi sarcoma virus oncogene homolog 1 | Vinexin, SH3 domain 3 | c-Jun-amino-terminal kinase interacting protein 2 |
| Cellular Rous sarcoma viral oncogene homolog | Peripheral plasma membrane protein CASK | Juvenile nephronophthisis protein |
| Ras GTPase-activating protein 1 | 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 | Crk-like protein, SH3 domain 2 |
| Intersectin, SH3 domain 1 | Ick/yes-related novel (LYN) protein tyrosine kinase | |
| Abelson-related protein, Arg | Cytoplasmic protein NCK2, SH3 domain 3 | Otoraplin |
| Fyn binding protein, SH3 domain 1 | Cellular Rous sarcoma viral oncogene homolog | FYN-binding protein, SH3 domain 2 |
| Presynaptic density protein 95 | Cytoplasmic protein NCK1, SH3 domain 2 | Zonula occludens 2 protein |
| Intersectin 1, SH3 domain 2 | Rho guanine nucleotide exchange factor 6 | Synapse-associated protein 97 (SAP97) |
| Spectrin alpha chain, erythrocyte | Rho-GTPase-activating protein 4 | GTPase-activating protein |
| Hemopoietic cell kinase | Presynaptic protein SAP102 | Megakaryocyte-associated tyrosine protein kinase |
| Rho guanine nucleotide exchange factor (GEF) 5 | CRK-associated substrate | SH3-containing GRB2-like protein 2 |
| Tyrosine protein, kinase TXK | SH3-containing GRB2-like protein 1 | Grb2-related adaptor protein, SH3 domain 2 |
| Interleukin-2-inducible T-cell kinase | Neutrophil cytosol factor 2, SH3 domain 2 | Melanoma inhibitory activity |
| Vav2 oncogene product, SH3 domain 2 | Myc box-dependent interacting protein 1 | SH3-containing GRB2-like protein 3 |
| Hematopoietic-specific protein 1 | Sorting nexin 9 | |
| Avian sarcoma virus CT10 oncogene homolog, SH3 domain 2 | Osteoclast stimulating factor 1 | |
| Neurite outgrowth factor or neutrophil cytosol factor 2, SH3 domain 1 | Embryonal Fyn-associated substrate | |
| Signal-transducing adaptor molecule | UBASH3 | |
a
SH3 domains that bound to GST-M2 are shown in bold type.