TABLE 5.

Mapping of anti-S MAbs targeting S1-RBD by binding competition assays^a

Group	Competing MAb	% Inhibition of binding by biotinylated MAb:
		102A12	119F8	121D7
S1-RBD-I	102A12	98.85	12.37	−213.26
	106C5	96.00	9.63	−108.06
	112B7	89.18	5.30	−131.89
S1-RBD-II	103D3	−18.56	95.07	4.52
	119F8	−28.16	87.67	−3.21
S1-RBD-III	106C7	−26.06	−4.80	91.27
	106H2	1.62	19.34	96.32
	109G7	−2.23	11.93	98.25
	121D7	14.11	30.25	97.97

^aCompeting MAbs were tested at 100 μg/ml for the ability to block binding of the biotinylated MAbs to RBD-Fc by ELISA. Greater than 40% inhibition was considered positive competition (values are shown in boldface type). Negative numbers indicate increased binding of the biotinylated reagent.