TABLE 1.
Level of replication in the upper and lower respiratory tracts of hamsters of rHMPVΔSH/G mutants bearing the indicated F cleavage sites
| Virusa | Mean peak titerb (log10 PFU/g ± SE) and % sheddingc from:
|
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|---|---|---|---|---|---|
| Nasal turbinates
|
Lungs
|
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| Day 3 | Day 5 | Day 7 | Day 3 | Day 5 | |
| FWT | 3.6 ± 0.3 | 4.2 ± 0.2 | 1.6 ± 0.4 (50%) | 2.6 ± 0.1 | 2.2 ± 0.3 (83%) |
| FAMPV-A | 3.7 ± 0.1 | 3.6 ± 0.2 | 1.2 ± 0.2 (66%) | 2.6 ± 0.0 | 1.9 ± 0.4 (83%) |
| FAMPV-C | 3.7 ± 0.2 | 4.0 ± 0.1 | 0.9 ± 0.2 (50%) | 2.7 ± 0.1 | 2.9 ± 0.1 |
| FS101P | 3.4 ± 0.2 | 3.4 ± 0.3 | 1.1 ± 0.3 (50%) | 2.5 ± 0.1 | 2.1 ± 0.2 (83%) |
a
Hamsters in groups of 18 were inoculated on day 0 by the intranasal route using a 0.1-ml inoculum containing 6.0 log10 PFU of the indicated virus.
b
The level of virus replication is expressed as the geometric mean of the peak virus titers (log10 PFU/gram ± standard errors) for the animals in each group. The lower limit of detection is 0.7 log10 PFU/g. A value of 0.7 log10 PFU/g is assigned to samples with no detectable virus; samples from lungs on day 7 had no detectable virus.
c
The percentage of shedding is indicated for each group when different from 0 or 100%.