TABLE 2.
Drug resistance profile of HIV mutants
| HIV cloneb | IC50 (nM) (fold increase) ofa:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| AZTc | PI
|
|||||||
| IDV | RTV | SQV | NFV | AZV | LPV | APV | ||
| 217 | 11 ± 2.1 (1.0) | 19 ± 4.5 (1.0) | 18 ± 4.5 (1.0) | 4.6 ± 1.8 (1.0) | 3.4 ± 0.9 (1.0) | 2.8 ± 0.6 (1.0) | 7.8 ± 1.7 (1.0) | 12 ± 2.3 (1.0) |
| 3116 | 26 ± 3.2 (2.4) | 310 ± 56 (16) | 1,700 ± 290 (94) | 210 ± 50 (46) | >1,000 (>290) | 25 ± 7.8 (8.9) | 30 ± 5.8 (3.8) | 203 ± 61 (17) |
| 3121 | 14 (1.3) | 24 ± 4.3 (1.3) | 153 ± 13 (8.5) | 15 ± 1.5 (3.3) | 35 ± 4.8 (10) | 7.6 ± 3.0 (2.6) | 14 ± 4.7 (1.8) | 36 ± 11 (3.0) |
| 3138 | 13 (1.2) | 11 ± 4.4 (0.6) | 43 ± 7.8 (2.4) | 5.0 ± 1.4 (1.1) | 15 ± 3.2 (4.4) | 1.5 ± 0.3 (0.5) | 2.4 ± 0.5 (0.3) | 4.5 ± 0.8 (0.4) |
a
Data show means ± standard errors of IC50s. Numbers in parentheses show relative increases compared with wild-type HIV217. The values were derived from at least three independent assays.
b
217, wild type; 3116, chimeric HIV containing 19I/E21D/A22V plus M46I/L63P/A71V/I84V/I93L; 3121, chimeric HIV containing M46I/L63P/A71V/I84V/I93L; 3138, recombinant HIV containing 19I/E21D/A22V.
c
AZT is an RT inhibitor.