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Frequency of resistant colony formation in the presence of single or combined NS5B polymerase inhibitors
| Parameter | NS5B polymerase inhibitorsa
|
|||
|---|---|---|---|---|
| 10× NNI-1 | 10× NNI-3 | 5× NNI-1, 5× NNI-3 | 10× NNI-1, 10× NNI-3 | |
| No. of coloniesb | 2,000c | 2,000c | 100 | 10 |
| Frequency (%)d | 1.3 | 1.3 | 0.06 | 0.006 |
Multiple of IC50 values.
Values represent the average results of three independent experiments.
Approximate number.
Frequency determined as (number of colonies/initial number of cells) × 100.
