FIG. 2.

Time course IF labeling experiment showing the development of SARS-CoV replicase signal in infected Vero E6 cells, as exemplified by labeling for nsp3. The initially punctate cytoplasmic staining (6 h p.i.) develops into a number of densely labeled areas close to the nucleus later in infection (9 and 12 h p.i.). Bar, 10 μm.