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. 2006 Jun;80(12):5976–5983. doi: 10.1128/JVI.00110-06

FIG. 5.

FIG. 5.

Histological findings from rhesus macaques infected with H5N1 viruses. (a) Section from a consolidated area from lungs shows bronchointerstitial pneumonia with severe infiltration of inflammatory cells (BHGs/QH/1/05 virus, day 7 postinfection) (HE stain). The lung lesions were distributed around the bronchioli. Asterisks indicate lumen of bronchioli. (b) Severe alveolar damage was observed within and along the periphery of the consolidated area (BHGs/QH/1/05 virus, day 7 postinfection) (HE stain). Severe proliferative and reactive hyperplasia of alveolar cells with massive recruitment of lymphocytes, fibrin exudates, and alveolar edema are shown. (c) A strong reaction with macrophages was one of the prominent findings in the lungs (BHGs/QH/1/05 virus, day 7 postinfection) (HE stain). (d) Severe alveolar edema, thickening of alveolar wall with lymphocyte recruitment (white arrow), and regeneration of alveolar cells (black arrow) were also observed (BHGs/QH/1/05 virus, day 7 postinfection) (HE stain). (e) The lung lesions were detected as peribronchiolitis in a macaque infected with DK/GX/35/01 virus at 4 days postinfection (DK/GX/35/01 virus, day 4 postinfection) (HE stain). The asterisk indicates lumen of bronchioles. (f) Prominent alveolar edema and strong reaction with foamy macrophages but scant regenerative change and scant lymphocytic recruitment in a macaque infected with DK/GX/35/01 virus (DK/GX/35/01 virus, day 7 postinfection) (HE stain). (g) Viral antigens in tonsilar epithelium on day 4 postinfection (brown) (BHGs/QH/1/05 virus, day 4 postinfection) (immunohistochemistry).