TABLE 2.
Linear associationa of HLA-B58s and HLA-C alleles with HIV-1 viral load in Zambians
| B58s and Cw alleles carried by group | Meanb | ΔVLc | P |
|---|---|---|---|
| B*5703-Cw*18 haplotype (n = 38)d | 4.24 | −0.47 | <0.001 |
| Cw*18+ B*5703+ (n = 38) vs. Cw*18+ B*5703− (n = 28) | 4.25 | −0.14 | 0.52 |
| Cw*18− B*5703+ (n = 8) vs. Cw*18− B*5703− (n = 348) | 5.0 | +0.27 | 0.31 |
| B*5703+ Cw*18+ (n = 38) vs. B*5703+ Cw*18− (n = 8) | 4.25 | −0.72 | <0.01 |
| B*5703− Cw*18+ (n = 28)f vs. B*5703− Cw*18− (n = 349) | 4.39 | −0.34 | 0.03 |
| B*5802-Cw*06 haplotype (n = 30)d | 4.95 | +0.31 | 0.03 |
| Cw*06+ B*5802+ (n = 30) vs. Cw*06+ B*5802− (n = 59) | 4.95 | +0.47 | <0.01 |
| Cw*06− B*5802+ (n = 2) vs. Cw*06− B*5802− (n = 332) | —e | — | — |
| B*5802− Cw*06+ (n = 59) vs. B*5802− Cw*06− (n = 332) | 4.48 | −0.19 | 0.14 |
| B*5801-Cw*03 haplotype (n = 13)d | 4.18 | −0.5 | 0.05 |
| Cw*03+ B*5801+ (n = 13) vs. Cw*03+ B*5801− (n = 39) | 4.23 | −0.52 | 0.07 |
| Cw*03− B*5801+ (n = 27) vs. Cw*03− B*5801− (n = 344) | 4.68 | +0.01 | 0.92 |
| B*5801+ Cw*03+ (n = 13) vs. B*5801+ Cw*03− (n = 27) | 4.23 | −0.43 | 0.12 |
| B*5801− Cw*03+ (n = 39) vs. B*5801−Cw*03− (n = 344) | 4.75 | +0.08 | 0.61 |
a
Assessed by GEE.
b
Corresponds to mean log10 VL of haplotype or the first group of comparison strata.
c
Corresponds to beta coefficients from the GEE models.
d
Compared to the absence of haplotype.
e
Not reported due to instability of estimates.
f
Six Cw*18-positive subjects had lower VLs (mean = 4.4, Δlog10 VL = −0.33, P = 0.3) after exclusion of 22 B*8101-positive subjects