FIG. 2.

Change in response to baseline autologous virus and to laboratory viruses over time in recent (A) and chronic (B) HIV disease. (A) Five acutely infected subjects initiated and later interrupted antiretroviral therapy. Viral rebound was associated with increased responses against contemporaneous virus (P = 0.04), the baseline autologous virus (P = 0.002), SF162 (P < 0.001), and NL4-3 (P < 0.001). The response to earlier autologous viruses was consistently higher than the response to autologous virus (data not shown). (B) The neutralizing responses to baseline autologous virus, SF162, and NL4-3 were measured over 1 year for 23 chronically infected subjects not modifying or initiating therapy. There was no evidence for a change over time (P of >0.30 for each virus). Changes in neutralizing antibody titers were analyzed using generalized estimating equations and assessed with nonlinear tests of trend. Median values and interquartile ranges are shown.